Isohanni I, Järvelin M R, Nieminen P, Jones P, Rantakallio P, Jokelainen J, Isohanni M
Polytechnic Institute of Oulu, Department of Public Health Science and General Practice, Medical Faculty, University of Oulu, Finland.
Psychol Med. 1998 Jul;28(4):967-74. doi: 10.1017/s0033291798006928.
Deterioration in school achievement may pre-date adult mental disorders. We studied the association between compulsory school performance and later onset hospital-treated psychiatric morbidity experienced by the Northern Finland 1966 Birth Cohort (N = 11017) in adult life.
School performance was operationalized in two ways: school class level (in normal, i.e. age-appropriate class v. not in normal class, i.e. class below age level or in special school) at the age of 14, and marks for individual school subjects at the age of 16. School class level was ascertained by postal questionnaire and school marks from national application register. These were linked to data on psychiatric morbidity from the National Finnish Hospital Discharge Register. By the end of 1994 (between ages 16 and 28 years), a total of 383 subjects had psychiatric illness. DSM-III-R diagnoses were grouped into three categories: schizophrenia; other psychoses; and non-psychotic disorders. The remaining population with no psychiatric hospitalization served as a single comparison group. School class level and values of school marks in the three diagnostic categories were each compared with this comparison group, stratified by sex.
In the comparison group 6.8% of boys and 3.4% of girls were not in their normal class. In all the diagnosis groups the proportions of those not in normal class were from 2 to 8 times higher than in the comparison group. A majority of those not in normal class and having psychiatric diagnosis were intellectually subnormal (IQ < 85). Among adolescents who later developed nonpsychotic disorders, means of school marks were lower (P < 0.05, adjusted for social class and place of residence) than in the comparison group. Lower marks were not found in categories schizophrenia or other psychoses. Logistic regression analysis confirmed these findings after adjustment for confounding factors.
Not being in the normal class at age 14 predicted future hospital-treated disorders, but low school marks at age 16 predicted only non-psychotic disorders. These findings may be an early manifestation of the disorders themselves, or a marker of vulnerability or other risk factors. The mechanisms may differ between diagnoses.
学业成绩的下降可能早于成人精神障碍的出现。我们研究了1966年芬兰北部出生队列(N = 11017)在成年期的义务教育表现与后来发生的需住院治疗的精神疾病之间的关联。
学业成绩通过两种方式衡量:14岁时的班级水平(在正常班级,即适龄班级,与不在正常班级,即低于适龄班级或在特殊学校),以及16岁时各学科的成绩。班级水平通过邮政问卷和国家申请登记册中的学校成绩确定。这些与芬兰国家医院出院登记册中的精神疾病数据相关联。到1994年底(年龄在16至28岁之间),共有383名受试者患有精神疾病。DSM-III-R诊断分为三类:精神分裂症;其他精神病;以及非精神病性障碍。其余未住院治疗精神疾病的人群作为一个单一的对照组。按性别分层,将三个诊断类别中的班级水平和学科成绩值与该对照组进行比较。
在对照组中,6.8%的男孩和3.4%的女孩不在正常班级。在所有诊断组中,不在正常班级的比例比对照组高出2至8倍。大多数不在正常班级且患有精神疾病诊断的人智力低于正常水平(智商<85)。在后来发展为非精神病性障碍的青少年中,学科成绩的平均值低于对照组(P<0.05,经社会阶层和居住地点调整)。在精神分裂症或其他精神病类别中未发现成绩较低的情况。逻辑回归分析在对混杂因素进行调整后证实了这些发现。
14岁时不在正常班级预示着未来需住院治疗的疾病,但16岁时的低学业成绩仅预示着非精神病性障碍。这些发现可能是疾病本身的早期表现,或者是易感性或其他风险因素的标志。不同诊断之间的机制可能不同。