Teirmaa T, Luukkaa V, Rouru J, Koulu M, Huupponen R
Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland.
Eur J Endocrinol. 1998 Aug;139(2):190-4. doi: 10.1530/eje.0.1390190.
Leptin is the hormonal product of the ob gene. It is expressed in adipocytes and participates in the regulation of food intake and metabolism. Since leptin also seems to signal metabolic information to the reproductive system, we studied the association between reproductive hormones and plasma leptin in normal-weight young women.
Eight young women with normal menstrual cycles (body mass index (BMI) 21.2 +/- 1.6 kg/m2) and eight young women using hormonal contraception (BMI 21.4 +/- 1.1 kg/m2) were studied. Furthermore, six women with normal menstrual cycles and no hormonal therapy (BMI 20.7 +/- 1.2 kg/m2) were studied around the time of the anticipated ovulation.
Serum leptin, estradiol, progesterone and luteinizing hormone (LH) concentrations were measured with radioimmunoassays.
Serum leptin concentrations were similar at the beginning of the cycle, at the time of the anticipated ovulation and at the end of the menstrual cycle (10.2 +/- 7.1, 10.7 +/- 7.0 and 11.8 +/- 6.9 microg/l respectively). There was an association between leptin and LH concentrations (r= 0.37, P< 0.01) when values recorded during different time points during the cycle were plotted with each other. There was no change in serum leptin in samples taken at different times of the cyclic treatment with an oral contraceptive. There was no significant difference in mean serum leptin concentrations between women using oral contraceptives and women with no hormonal therapy.
There is a link between serum leptin and LH concentrations during the menstrual cycle. Variations in circulating estrogen and/or progesterone concentrations have no major influence on circulating leptin in young female subjects.
瘦素是肥胖基因的激素产物。它在脂肪细胞中表达，并参与食物摄入和新陈代谢的调节。由于瘦素似乎也向生殖系统传递代谢信息，我们研究了正常体重年轻女性生殖激素与血浆瘦素之间的关联。
对8名月经周期正常的年轻女性（体重指数（BMI）21.2±1.6kg/m²）和8名使用激素避孕的年轻女性（BMI 21.4±1.1kg/m²）进行了研究。此外，对6名月经周期正常且未接受激素治疗的女性（BMI 20.7±1.2kg/m²）在预期排卵时间前后进行了研究。
采用放射免疫分析法测定血清瘦素、雌二醇、孕酮和促黄体生成素（LH）浓度。
在月经周期开始时、预期排卵时和月经周期结束时，血清瘦素浓度相似（分别为10.2±7.1、10.7±7.0和11.8±6.9μg/l）。当将周期中不同时间点记录的值相互绘制时，瘦素与LH浓度之间存在关联（r = 0.37，P<0.01）。口服避孕药进行周期治疗的不同时间采集的样本中血清瘦素无变化。使用口服避孕药的女性与未接受激素治疗的女性之间的平均血清瘦素浓度无显著差异。
月经周期中血清瘦素与LH浓度之间存在联系。循环雌激素和/或孕酮浓度的变化对年轻女性受试者循环瘦素没有重大影响。
