Doss B J, Vicari J, Jacques S M, Qureshi F
Department of Pathology, Hutzel Hospital and Wayne State University School of Medicine, 4707 St. Antoine Boulevard, Detroit, MI 48201, USA.
Pediatr Dev Pathol. 1998 Nov-Dec;1(6):538-42. doi: 10.1007/s100249900074.
We describe extensive placental involvement by hepatoblastoma in a 2600 g, 33-week estimated gestational age (EGA) hydropic female fetus with the hepatoblastoma otherwise limited to the liver. The placenta weighed 1190 g and histopathologic examination revealed diffuse tumor emboli in chorionic villous vessels. The placental tumor exhibited a cytologic appearance similar to the primary tumor and showed strong alpha-fetoprotein staining. Although unusual, other congenital tumors, including neuroblastoma and leukemia, have also been described metastatic to the placenta. This case emphasizes the important role of careful histopathologic examination of the placenta which, combined with immunohistochemistry and clinicopathologic correlation, may establish a diagnosis and possibly obviate the need for invasive neonatal diagnostic procedures.
我们描述了一例2600克、估计孕龄33周的水肿女胎，其肝母细胞瘤广泛累及胎盘，而肝母细胞瘤仅局限于肝脏。胎盘重1190克，组织病理学检查显示绒毛膜血管内有弥漫性肿瘤栓子。胎盘肿瘤的细胞学表现与原发肿瘤相似，且甲胎蛋白染色呈强阳性。虽然不常见，但其他先天性肿瘤，包括神经母细胞瘤和白血病，也有转移至胎盘的报道。该病例强调了对胎盘进行仔细组织病理学检查的重要作用，结合免疫组化和临床病理相关性分析，可能有助于确诊，甚至避免新生儿进行侵入性诊断操作。
