Intestinal intraepithelial T lymphocytes. Our T cell horizons are expanding.

The alimentary tract is an essential structure for the ingesting of nutrients from the outside, and even most primitive animals have a straight tract that runs from the mouth to the anus. We come into contact with the outside world through our skin and mucous membranes. The surface area of the enteric mucous membrane, which absorbs nutrients, is enlarge through its ciliary structure, and the enteric cavity creates by far the largest external world that we come into contact with. For instance, the enteric mucosal surface of the human gastrointestinal tract covered by a single layer of epithelial cells corresponds to the size of one-and-a-half tennis courts, and the innumerable number of epithelial cells covering this mucous surface are entirely replaced by new epithelial cells in the space of just several days. Simultaneously, the fact that 60-70% of peripheral lymphocytes are congregating in the gastrointestinal tract supports the notion that the enteric mucous membrane represents an extremely dangerous locale, where numerous harmless/precarious external antigens come in through the wide array of food we injest on a daily basis, and the literally infinite amounts of normal intestinal flora intermingled from time to time with life-threatening microbes surge across. Surprisingly, approximately one out of the five cells in the intestinal epithelium are lymphocytes, most of which are ill-defined T cells having unusual, but distinctive characteristics and situated apparently so close to external antigens in the entire body. This article deals with the information that has been accumulated mainly in the past decade concerning the development, phenotypes, and possible function of these yet unacknowledged mucosal T cells that lurk in the anatomical front of the intestine.