Role of T lymphocytes and cytokines in coccidiosis.

Development of a vaccine for avian coccidiosis has been hampered by lack of understanding of the various components of the host immune system leading to protective immunity. Clear understanding of the cellular dichotomy in cytokine production in mice and the availability of immunological reagents, as well as gene knock-out mice, now makes in-depth immunological study in this species feasible. From studies of various parasitic infection models in mice, it is becoming clear that complex regulation by cytokines is involved in host immunity. Furthermore, the studies in mice clearly indicated an important role of various effector mechanisms involving T lymphocytes, macrophages, natural killer (NK) cells and cytokines in resistance to coccidiosis. In comparative studies of coccidiosis in chickens, in-vivo and in-vitro studies revealed that interferon-gamma, tumor necrosis factor and transforming growth factor-beta are induced following Eimeria infection. Depletion studies revealed the importance of CD8+TCR-alpha-beta+ T lymphocytes in host protective immunity to avian coccidiosis. Taken together, studies in mice and chickens are providing a better understanding of the role of effector cells and soluble factors which control immune responses to Eimeria parasites.