McGrory C H, Radomski J S, Moritz M J, Armenti V T
Department of Surgery, Thomas Jefferson University, Philadelphia, Pa., USA.
J Transpl Coord. 1998 Mar;8(1):55-9. doi: 10.7182/prtr.1.8.1.w3128326211737k1.
Female recipients of pancreas-kidney transplants may have an increased chance for pregnancy, because transplantation often restores fertility. Data on pregnancy after pancreas-kidney transplantation were analyzed by the National Transplantation Pregnancy Registry at US transplant centers. Ten recipients who were on cyclosporine-based immunosuppression were studied. A total of 15 pregnancies had resulted, of which 12 were live births. Among the 12 newborns, prematurity and low birth weight occurred in 75% and 83% of the cases, respectively. Three had complications associated with prematurity. Two thirds of the infants were delivered by cesarean section. All children are developing well with no apparent residual problems. During pregnancy, hypertension and urinary tract infections occurred frequently among recipients. Two recipients had three subsequent graft losses within 2 years of giving birth; however, both were successfully retransplanted. Successful pregnancy is possible for female pancreas-kidney recipients.
接受胰肾移植的女性怀孕几率可能会增加，因为移植手术常常能恢复生育能力。美国移植中心的国家移植妊娠登记处分析了胰肾移植后妊娠的数据。对10名接受基于环孢素的免疫抑制治疗的受者进行了研究。总共发生了15次妊娠，其中12次为活产。在这12名新生儿中，早产和低体重出生的发生率分别为75%和83%。3名新生儿出现了与早产相关的并发症。三分之二的婴儿通过剖宫产分娩。所有儿童发育良好，没有明显的遗留问题。在怀孕期间，受者中高血压和尿路感染频繁发生。两名受者在分娩后2年内出现了3次移植肾失功；然而，两人均成功接受了再次移植。接受胰肾移植的女性有可能成功怀孕。
