Fye M A, Southern E P, Panjabi M M, Cholewicki J
Department of Orthopaedics, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
J Spinal Disord. 1998 Aug;11(4):335-40.
Quantitative discomanometry is a study of intradiscal pressure and volume measurements during the injection of fluid into an endplate-disc-endplate complex. The purpose of this article was to describe the technique of quantitative discomanometry, determine the reproducibility of the injection technique in a cadaveric thoracolumbar spine, and standardize the technique for future clinical investigations. Nineteen fresh human cadaveric thoracolumbar discs were injected using quantitative discomanometry to determine: (a) the time necessary for a disc to return to a baseline pressure-volume curve, (b) the reproducibility of the technique in vitro, (c) effects of the injection approach and position of the needle in the disc, and (d) effects of the type and length of tubing as well as gauge of spinal needle. A pressure-volume curve was obtained for each disc injection. Reproducibility was measured by nine parameters obtained from each pressure-volume curve: intrinsic pressure, leakage pressure, initial slope, slope between 0-0.1 ml, slope between 1-4 ml, pressure at 2 ml, pressure at 4 ml, maximum pressure, and volume at maximum pressure. The results demonstrated that (a) the injector apparatus was reproducible, (b) the time necessary for a disc to return to a baseline pressure-volume curve was 24 h, (c) the technique using fresh human cadaveric thoracolumbar discs was reproducible, (d) the anterior and posterolateral approaches had similar results if the needle was placed into the center of the nucleus pulposus using radiographic control, and (e) the type and length of tubing, and gauge of needle did not affect the results.
定量椎间盘测压法是一项在向终板 - 椎间盘 - 终板复合体注入液体过程中测量椎间盘内压力和容积的研究。本文的目的是描述定量椎间盘测压法的技术，确定该注射技术在尸体胸腰椎脊柱中的可重复性，并为未来的临床研究规范该技术。使用定量椎间盘测压法对19个新鲜人类尸体胸腰椎椎间盘进行注射，以确定：（a）椎间盘恢复到基线压力 - 容积曲线所需的时间，（b）该技术在体外的可重复性，（c）注射方法和针在椎间盘中的位置的影响，以及（d） tubing的类型和长度以及脊柱针的规格的影响。每次椎间盘注射均获得一条压力 - 容积曲线。通过从每条压力 - 容积曲线获得的九个参数测量可重复性：固有压力、渗漏压力、初始斜率、0 - 0.1 ml之间的斜率、1 - 4 ml之间的斜率、2 ml时的压力、4 ml时的压力、最大压力以及最大压力时的容积。结果表明：（a）注射装置具有可重复性，（b）椎间盘恢复到基线压力 - 容积曲线所需的时间为24小时，（c）使用新鲜人类尸体胸腰椎椎间盘的技术具有可重复性，（d）如果在影像学控制下将针置于髓核中心，则前外侧和后外侧入路的结果相似，并且（e） tubing的类型和长度以及针的规格不影响结果。
