椎间盘退变：一项将磁共振成像与定量椎间盘测压术相关联的人体尸体研究。
Disc degeneration: a human cadaveric study correlating magnetic resonance imaging and quantitative discomanometry.
作者信息
Southern E P, Fye M A, Panjabi M M, Patel T C, Cholewicki J
机构信息
Memorial Orthopaedic Surgical Group, Long Beach, California, USA.
出版信息
Spine (Phila Pa 1976). 2000 Sep 1;25(17):2171-5. doi: 10.1097/00007632-200009010-00005.
STUDY DESIGN
This human cadaveric study evaluated disc degeneration of the lumbar spine using magnetic resonance imaging and quantitative discomanometry.
OBJECTIVE
To determine if a correlation exists between magnetic resonance imaging and quantitative discomanometry in determining disc degeneration of the lumbar spine.
SUMMARY OF BACKGROUND DATA
Several studies analyzing disc degeneration of the lumbar spine have compared magnetic resonance imaging with discography and discomanometry. The reported results are conflicting. No studies exist that compare magnetic resonance imaging and quantitative discomanometry in assessing the disc degeneration of the lumbar spine.
METHODS
Three fresh human cadaveric thoracolumbar spine specimens (two T11-S1 and one L1-S1) that included a total of 19 discs were used. Spines were scanned with magnetic resonance imaging, and the scans were read by a neuroradiologist. Using the quantitative discomanometry technique, discs were injected with normal saline, and pressure-volume curves were collected and quantified with six parameters: intrinsic pressure, leakage pressure, initial slope, slope from 0.0 to 0.1 mL, maximum pressure, and volume at maximum pressure. Data analysis was performed using Spearman's Rank Correlation (Rho) statistic.
RESULTS
Based on the results from 19 discs, an overall good correlation between magnetic resonance imaging scores and the six quantitative discomanometry parameters was demonstrated. With exception of the volume at maximum pressure, correlation coefficients ranged between 0.61 to 0.78 with a P < 0.05.
CONCLUSIONS
Magnetic resonance imaging scores and quantitative discomanometry parameters correlated well in the assessment of disc degeneration of the lumbar spine. Quantitative discomanometry may be an important technique for evaluating early disc degeneration, especially tears of the anular fibers, which may be missed on magnetic resonance imaging.
研究设计
这项人体尸体研究使用磁共振成像和定量椎间盘测压法评估腰椎间盘退变情况。
目的
确定在判定腰椎间盘退变时，磁共振成像与定量椎间盘测压法之间是否存在相关性。
背景资料概述
多项分析腰椎间盘退变的研究已将磁共振成像与椎间盘造影术和椎间盘测压法进行了比较。报道的结果相互矛盾。尚无研究比较磁共振成像和定量椎间盘测压法在评估腰椎间盘退变方面的情况。
方法
使用了三个新鲜的人体胸腰椎脊柱标本（两个T11-S1和一个L1-S1），共包含19个椎间盘。对脊柱进行磁共振成像扫描，并由神经放射科医生解读扫描结果。采用定量椎间盘测压技术，向椎间盘内注入生理盐水，并收集压力-容积曲线，并用六个参数进行量化：固有压力、渗漏压力、初始斜率、0.0至0.1 mL时的斜率、最大压力以及最大压力时的容积。使用Spearman等级相关（Rho）统计量进行数据分析。
结果
基于19个椎间盘的结果，显示磁共振成像评分与六个定量椎间盘测压参数之间总体具有良好的相关性。除最大压力时的容积外，相关系数在0.61至0.78之间，P < 0.05。
结论
在评估腰椎间盘退变时，磁共振成像评分与定量椎间盘测压参数具有良好的相关性。定量椎间盘测压法可能是评估早期椎间盘退变的一项重要技术，尤其是在磁共振成像上可能遗漏的纤维环撕裂情况。
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