Jelkmann W
Institute of Physiology, Medical University of Luebeck, Germany.
J Interferon Cytokine Res. 1998 Aug;18(8):555-9. doi: 10.1089/jir.1998.18.555.
The plasma level of erythropoietin (Epo) in anemic patients suffering from inflammation is often low in relation to the blood hemoglobin concentration. Various proinflammatory cytokines have been tested for their action on the synthesis of Epo. Interleukin 1 (IL-1) and tumor necrosis factor-alpha(TNF-alpha) suppress Epo gene expression in isolated perfused rat kidneys and in human hepatoma cell cultures. IL-6 inhibits in the kidney, and conflicting results have been reported for its effect on Epo synthesis in hepatic cells. Several other cytokines tested were without effect. Thus, mainly IL-1 and TNF-alpha seem to be responsible for the defect in Epo production in severe systemic and renal inflammatory diseases.
患有炎症的贫血患者的促红细胞生成素（Epo）血浆水平相对于血液血红蛋白浓度往往较低。已经对多种促炎细胞因子对Epo合成的作用进行了测试。白细胞介素1（IL-1）和肿瘤坏死因子-α（TNF-α）可抑制离体灌注大鼠肾脏和人肝癌细胞培养物中的Epo基因表达。IL-6在肾脏中起抑制作用，而关于其对肝细胞中Epo合成的影响则报道了相互矛盾的结果。测试的其他几种细胞因子没有作用。因此，主要是IL-1和TNF-α似乎是导致严重全身性和肾脏炎症性疾病中Epo产生缺陷的原因。
