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转基因瘤胃细菌可保护绵羊免受氟乙酸盐中毒。

Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning.

作者信息

Gregg K, Hamdorf B, Henderson K, Kopecny J, Wong C

机构信息

Rumen Biotech, Murdoch University, Murdoch, Western Australia 6150, Australia.

出版信息

Appl Environ Microbiol. 1998 Sep;64(9):3496-8. doi: 10.1128/AEM.64.9.3496-3498.1998.

DOI:10.1128/AEM.64.9.3496-3498.1998
PMID:9726903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC106753/
Abstract

Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 10(6) to 10(7) cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control sheep.

摘要

四株用编码氟乙酸脱卤酶的基因转化的溶纤维丁酸弧菌，在试验绵羊瘤胃中的细胞总数维持在10⁶至10⁷个/毫升。与五只未接种的对照绵羊相比，当比较行为、生理和组织学效应时，五只接种的绵羊在氟乙酸中毒后毒理学症状明显减轻。

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本文引用的文献

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Fluoroacetate poisoning in sheep.绵羊中的氟乙酸盐中毒。
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2
Group-specific 16S rRNA hybridization probes for determinative and community structure studies of Butyrivibrio fibrisolvens in the rumen.用于瘤胃中溶纤维丁酸弧菌鉴定及群落结构研究的群特异性16S rRNA杂交探针。
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Detoxification of the plant toxin fluoroacetate by a genetically modified rumen bacterium.利用基因改造瘤胃细菌对植物毒素氟乙酸盐进行解毒
Biotechnology (N Y). 1994 Dec;12(13):1361-5. doi: 10.1038/nbt1294-1361.
5
Engineering gut flora of ruminant livestock to reduce forage toxicity: progress and problems.改造反刍家畜肠道菌群以降低草料毒性：进展与问题
Trends Biotechnol. 1995 Oct;13(10):418-21. doi: 10.1016/S0167-7799(00)88995-7.
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