转基因瘤胃细菌可保护绵羊免受氟乙酸盐中毒。
Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning.
作者信息
Gregg K, Hamdorf B, Henderson K, Kopecny J, Wong C
机构信息
Rumen Biotech, Murdoch University, Murdoch, Western Australia 6150, Australia.
出版信息
Appl Environ Microbiol. 1998 Sep;64(9):3496-8. doi: 10.1128/AEM.64.9.3496-3498.1998.
Abstract
Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 10(6) to 10(7) cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control sheep.
摘要
四株用编码氟乙酸脱卤酶的基因转化的溶纤维丁酸弧菌，在试验绵羊瘤胃中的细胞总数维持在10⁶至10⁷个/毫升。与五只未接种的对照绵羊相比，当比较行为、生理和组织学效应时，五只接种的绵羊在氟乙酸中毒后毒理学症状明显减轻。
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