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牛奶及其他饮食因素对冠心病的影响。

Milk and other dietary influences on coronary heart disease.

作者信息

Grant W B

机构信息

NASA Langley Research Center, Hampton, Va., USA.

出版信息

Altern Med Rev. 1998 Aug;3(4):281-94.

PMID:9727089
Abstract

While dietary links to ischemic heart disease (IHD) and coronary heart disease (CHD) mortality have been studied for many years, the correlation has not clearly been resolved, especially for older populations. In this paper, a multi-country statistical approach involving 32 countries is used to find dietary links to IHD and CHD for various age groups aged 35+. For IHD, milk carbohydrates were found to have the highest statistical association for males aged 35+ and females aged 65+, while for females aged 35-64, sugar was found to have the highest association. In the case of CHD, non-fat milk was found to have the highest association for males aged 45+ and females aged 75+, while for females 65-74, milk carbohydrates and sugar had the highest associations, and for females aged 45-64, sugar had the highest association. A number of mechanisms have been proposed in the literature that might explain the milk carbohydrate or non-fat milk association. One of the most prominent theories is that animal proteins contribute to homocysteine (Hcy) production; however, milk more than meat lacks adequate B vitamins to convert Hcy to useful products. Lactose and calcium in conjunction with Hcy from consumption of non-fat milk may also contribute to calcification of the arteries.

摘要

虽然饮食与缺血性心脏病(IHD)和冠心病(CHD)死亡率之间的联系已研究多年,但这种关联尚未明确解决,尤其是在老年人群中。本文采用涉及32个国家的多国统计方法,来寻找35岁及以上不同年龄组饮食与IHD和CHD之间的联系。对于IHD,发现牛奶碳水化合物与35岁及以上男性和65岁及以上女性的关联最为显著,而对于35 - 64岁的女性,糖的关联最为显著。对于CHD,发现脱脂牛奶与45岁及以上男性和75岁及以上女性的关联最为显著,而对于65 - 74岁的女性,牛奶碳水化合物和糖的关联最为显著,对于45 - 64岁的女性,糖的关联最为显著。文献中提出了一些机制,可能解释牛奶碳水化合物或脱脂牛奶的关联。最突出的理论之一是动物蛋白会导致同型半胱氨酸(Hcy)生成;然而,牛奶比肉类缺乏足够的B族维生素来将Hcy转化为有用的产物。脱脂牛奶中的乳糖、钙与摄入的Hcy结合,也可能导致动脉钙化。

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