Kuchar M
Výzkumný ústav pro farmacii a biochemii, Praha.
Cas Lek Cesk. 1998 May 25;137(11):323-9.
The objective of the article is to make readers familiar with contemporary methods of research and development of original drugs and elucidate economic aspects of pharmaceutical research. The contemporary strategy of research and development in the Research Institute for Pharmacy and Biochemistry is discussed in relation to general trends. Pharmaceutical research and development are characterized by high costs which vary in the majority of pharmaceutical companies engaged in the development of new drugs between 12-16% of the total turnover. The author discusses problems associated with the return rate of these investments in conjunction with patent protection and the time taken to develop original drugs. Expedient use of the large financial funds calls for rational management of research and development. The author therefore pays attention to an analysis of rational methods of management of research and development which are applied in the selection of a research programme and of research projects, to modern methods of research and to the organization of research and development. The author deals subsequently in more detail with contemporary methods of research focused on the detection of leading structures, where molecular modelling and technology of combinatorial chemistry are used. By their combination with optimization procedures using statistical data analysis rational design of molecules is made possible.
本文的目的是使读者熟悉原创药物研发的当代方法，并阐明药物研究的经济方面。结合总体趋势，讨论了药物与生物化学研究所当代的研发策略。药物研发的特点是成本高昂，大多数从事新药研发的制药公司的研发成本占总营业额的12%至16%。作者结合专利保护以及研发原创药物所需的时间，讨论了这些投资回报率相关的问题。合理使用大量资金需要对研发进行合理管理。因此，作者关注对研发合理管理方法的分析，这些方法应用于研究计划和研究项目的选择、现代研究方法以及研发组织。作者随后更详细地探讨了专注于发现先导结构的当代研究方法，其中使用了分子建模和组合化学技术。通过将它们与使用统计数据分析的优化程序相结合，分子的合理设计成为可能。
