Kimura K, Kagami S, Ikeda Y, Takahashi H, Yoshihama M, Kusakabe H, Osada H, Isono K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.
J Antibiot (Tokyo). 1998 Jul;51(7):640-6. doi: 10.7164/antibiotics.51.640.
Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was identified as a Streptomyces sp. from its cultural characteristics and physiological properties. It produced new types of liposidomycins that lacked sulfate and/or 3-methylglutaric acid moieties present in known liposidomycins by changing medium components. Sucrose and malt extract were particularly suitable sources for specific production of the new types of liposidomycins.
脂糖霉素是一类非典型的含脂核苷抗生素，可抑制细菌肽聚糖的合成。根据其培养特性和生理特性，确定其产生菌为链霉菌属的一个菌株。通过改变培养基成分，该菌株产生了新型脂糖霉素，这些新型脂糖霉素缺乏已知脂糖霉素中存在的硫酸根和/或3-甲基戊二酸部分。蔗糖和麦芽提取物是特异性生产新型脂糖霉素的特别合适的来源。
