Szabo G
Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA.
Alcohol Clin Exp Res. 1998 Aug;22(5 Suppl):216S-219S. doi: 10.1097/00000374-199805001-00002.
The immunomodulatory capacity of acute, moderate alcohol consumption was investigated in this study in nonalcoholic volunteers after 2 ml of vodka/kg body weight of alcohol consumption. There was a significant, transient increase in interleukin-12 and interferon-gamma (IFNgamma) levels in whole blood samples collected 4 hr after alcohol consumption in response to an ex vivo bacterial challenge with lipopolysaccharide (p < 0.02). However, decreased IFNgamma levels were produced by mononuclear cells collected later after alcohol consumption (16 hr), suggesting that acute alcohol consumption has a biphasic effect on IFNgamma inducibility. Furthermore, isolated blood monocytes collected 16 hr after alcohol consumption showed significantly decreased IL-1beta production in response to subsequent bacterial stimulation, implying that in vivo alcohol consumption affects monocyte-derived inflammatory cytokine production. These results demonstrate that even acute, moderate alcohol consumption has a modulating capacity on immune functions that may contribute to decreased immunity and host defense.
本研究在非酒精性志愿者中，给予每千克体重2毫升伏特加的酒精摄入量后，调查了急性适度饮酒的免疫调节能力。饮酒4小时后采集的全血样本，在经脂多糖进行体外细菌刺激后，白细胞介素-12和干扰素-γ（IFNγ）水平出现显著短暂升高（p < 0.02）。然而，饮酒后较晚时间（16小时）采集的单核细胞产生的IFNγ水平降低，表明急性饮酒对IFNγ诱导性具有双相效应。此外，饮酒16小时后分离的血液单核细胞，在随后受到细菌刺激时，IL-1β产生显著减少，这意味着体内饮酒会影响单核细胞衍生的炎性细胞因子产生。这些结果表明，即使是急性适度饮酒也对免疫功能具有调节能力，这可能导致免疫力和宿主防御能力下降。
