Goodall C M, Lijinsky W
Pathology. 1976 Apr;8(2):143-9. doi: 10.3109/00313027609094440.
Whole-of-life tests of the C-nitroso compounds p-nitrosodimethylaniline (NDMA) and p-nitroso-diethylaniline (NDEA) have been completed in male rats and mice fed maximum tolerated doses continuously over the first halves of their respective natural lifespans. The chemicals were offered at a concentration of 300 mg/litre drinking fluid, but the doses of NDEA consumed were only 75% of the NDMA doses, in both species. Possibly because of this the results with NDEA were statistically not clear-cut, but there was a significant increase in tumour incidence after NDMA treatment in both species. The main sites of tumorigenesis after NDMA were lung, kidney and malignant lymphoma in the rats, and lung, duodenum and malignant lymphoma in the mice. The results confirm our own earlier experiment and provide the first evidence of oncogenic activity in this class of compounds.
对C-亚硝基化合物对亚硝基二甲基苯胺（NDMA）和对亚硝基二乙苯胺（NDEA）进行了终生试验，在雄性大鼠和小鼠中，在其各自自然寿命的前半期连续喂食最大耐受剂量。化学物质以300毫克/升的饮水浓度提供，但在两个物种中，NDEA的摄入量仅为NDMA剂量的75%。可能由于这个原因，NDEA的结果在统计学上并不明确，但在两个物种中，NDMA处理后肿瘤发生率都有显著增加。NDMA处理后，大鼠的主要肿瘤发生部位是肺、肾和恶性淋巴瘤，小鼠的主要肿瘤发生部位是肺、十二指肠和恶性淋巴瘤。这些结果证实了我们自己早期的实验，并提供了这类化合物致癌活性的首个证据。
