Sajjad S H
Department of Psychiatry, School of Post Graduate Medicine, Keele University, Stoke on Trent, Staffordshire, UK.
Int Clin Psychopharmacol. 1998 Jul;13(4):147-55. doi: 10.1097/00004850-199807000-00001.
Vitamin E has been suggested to be a promising new treatment for tardive dyskinesia. However, little is known about the optimum dose. Twenty patients with tardive dyskinesia whose medication had been unchanged for at least 1 month were selected and randomly divided into a treatment group with 11 patients and a control group with nine patients. The treatment group was started on 600 mg of vitamin E per day, and this dose was increased over the 7 months of the trial to 1600 mg per day. The medication for the control group was unchanged. Severity of tardive dyskinesia was rated on the Abnormal Involuntary Movement Scale. Patients in the treatment group initially showed a significant response to the lower dose of 600 mg per day. However, this improvement was not maintained and differences between the two groups reached significant levels only after the dose of vitamin E was increased to 1600 mg per day. At this dose, there was a significant and sustained reduction in the severity of tardive dyskinesia. The results suggest that vitamin E is of value in the treatment of tardive dyskinesia and that the optimum dose for treating tardive dyskinesia is 1600 mg per day. In addition, there may be a dose related therapeutic effect of Vitamin E in tardive dyskinesia.
维生素E已被认为是迟发性运动障碍一种有前景的新疗法。然而，关于最佳剂量却知之甚少。选取20例迟发性运动障碍患者，其用药至少1个月未变，随机分为治疗组（11例患者）和对照组（9例患者）。治疗组开始时每天服用600毫克维生素E，在7个月的试验过程中，该剂量增加至每天1600毫克。对照组用药不变。迟发性运动障碍的严重程度根据异常不自主运动量表进行评定。治疗组患者最初对每天600毫克的较低剂量有显著反应。然而，这种改善未能持续，仅在维生素E剂量增加至每天1600毫克后，两组之间的差异才达到显著水平。在此剂量下，迟发性运动障碍的严重程度有显著且持续的降低。结果表明，维生素E在治疗迟发性运动障碍方面有价值，治疗迟发性运动障碍的最佳剂量是每天1600毫克。此外，维生素E在迟发性运动障碍中可能存在剂量相关的治疗效果。
