Barak Y, Swartz M, Shamir E, Stein D, Weizman A
Abarbanel Mental Health Center, Bat-Yam, Israel.
Ann Clin Psychiatry. 1998 Sep;10(3):101-5. doi: 10.1023/a:1022349920283.
Tardive dyskinesia is an involuntary movement disorder developing following treatment with neuroleptics. As many as 50% of chronic psychotic patients develop this disabling condition. No treatment has been found effective for tardive dyskinesia. This study was undertaken to meta-analyze the effects of vitamin E (alpha-tocopherol) reported in the last decade. All studies published since 1987, focusing on vitamin E and tardive dyskinesia are reviewed. Double-blind studies are analyzed using measures of effect and variance as described by secondary analysis of magnitude of effects in pooled data. A total of 223 patients received vitamin E treatment (400-1600 IU/day) for tardive dyskinesia, in 12 studies. A significant subgroup (28.3%) showed a modest improvement. Vitamin E was well tolerated, and only rarely did side effects occur-of no clinical significance. Vitamin E is a safe, well-tolerated compound that may provide some beneficial effects in patients suffering from neuroleptic-induced tardive dyskinesia.
迟发性运动障碍是一种在使用抗精神病药物治疗后出现的不自主运动障碍。多达50%的慢性精神病患者会发展成这种致残性疾病。目前尚未发现对迟发性运动障碍有效的治疗方法。本研究旨在对过去十年中报道的维生素E（α-生育酚）的疗效进行荟萃分析。回顾了自1987年以来发表的所有聚焦于维生素E和迟发性运动障碍的研究。采用合并数据中效应大小的二次分析所描述的效应量和方差测量方法对双盲研究进行分析。在12项研究中，共有223例迟发性运动障碍患者接受了维生素E治疗（400 - 1600国际单位/天）。一个显著的亚组（28.3%）显示出适度改善。维生素E耐受性良好，仅偶尔出现无临床意义的副作用。维生素E是一种安全、耐受性良好的化合物，可能对患有抗精神病药物所致迟发性运动障碍的患者产生一些有益作用。
