van Wieringen P M, Monnens L A, Bakkeren J A
Pediatrics. 1976 Oct;58(4):561-3.
In children with hemolytic-uremic syndrome endotoxin determinations were carried out in the peripheral circulation in order to get evidence for the hypothetical role of endotoxin in the pathogenesis of the disease. For this purpose the Limulus test was used to determine endotoxin activity in 16 patients with hemolytic-uremic syndrome. In the plasma of these patients no endotoxin could be detected above the lower detection limit of 100 pg/ml, although in all patients with septicemia due to gram-negative bacilli the test was positive.
为了证实内毒素在溶血尿毒综合征发病机制中所假设的作用，对溶血尿毒综合征患儿的外周循环进行了内毒素测定。为此，采用鲎试剂法对16例溶血尿毒综合征患者的内毒素活性进行了测定。这些患者血浆中未检测到高于100 pg/ml检测下限的内毒素，尽管所有革兰阴性杆菌败血症患者的检测结果均为阳性。
