Nolin L, O'Regan S, Pelletier M, Rivard G E, Mongeau J G, Robitaille P
Clin Exp Immunol. 1979 Jan;35(1):107-11.
Ultrastructural and immunofluorescent microscopic studies were performed on renal tissue obtained from nine patients during the acute and convalescent phase of the haemolytic uraemic syndrome (HUS). All had glomerular deposits of IgM in the absence of circulating immune complexes. This was associated with deposition of C1q during the acute phase, and properdin and C3 during the convalescent phase. C4 was consistently absent. Since such a pattern of complement deposition does not fulfil criteria either for alternate or classical pathway activation, the possibility of C1q bypass loop activation by IgM is suggested.
对9例溶血性尿毒症综合征（HUS）患者急性期和恢复期的肾组织进行了超微结构和免疫荧光显微镜研究。所有患者均有IgM的肾小球沉积，且无循环免疫复合物。这与急性期C1q沉积以及恢复期备解素和C3沉积相关。C4始终缺失。由于这种补体沉积模式不符合替代途径或经典途径激活的标准，提示存在IgM激活C1q旁路途径的可能性。
