McAllister B S, Margolin M D, Cogan A G, Taylor M, Wollins J
Department of Periodontology, Northwest Wound Healing Center, Oregon Health Sciences University, Portland 97201, USA.
Int J Periodontics Restorative Dent. 1998 Jun;18(3):227-39.
Sinus grafting procedures are a viable means of ensuring adequate bone for the placement of dental implants in the posterior maxilla. In the quest to improve predictability and accelerate the time line toward receiving a final prosthesis, researchers have turned to recombinant human proteins like osteogenic protein-1 for the potential to therapeutically enhance bone formation. Bilateral sinus augmentations were performed in 15 adults chimpanzees to evaluate treatment with different doses of the osteogenic protein-1 device or natural bone mineral (Bio-Oss). Methods of evaluation included soft tissue healing, radiography (computed tomographic scan), histology, residual lateral wall defect surface area at 7.5 months, and the extent of soft tissue encleftation at 7.5 months. Findings revealed radiographic and histologic evidence of bone formation with all treatment groups and a statistically significant reduction in the depth of soft tissue encleftation and the residual lateral wall defect surface area for both the Bio-Oss and the 2.5-mg osteogenic protein-1 per gram collagen matrix treatments when compared to collagen matrix alone. These results suggest that Bio-Oss and the 2.5-mg osteogenic protein-1 per gram collagen matrix effectively stimulate bone formation in the maxillary sinus.
窦底植骨术是确保上颌后牙区有足够骨量以植入牙种植体的一种可行方法。为了提高可预测性并缩短获得最终修复体的时间，研究人员开始关注重组人蛋白，如骨形成蛋白-1，其具有治疗性增强骨形成的潜力。对15只成年黑猩猩进行双侧窦底增高术，以评估不同剂量的骨形成蛋白-1装置或天然骨矿物质（Bio-Oss）的治疗效果。评估方法包括软组织愈合情况、影像学检查（计算机断层扫描）、组织学检查、7.5个月时的残余侧壁缺损表面积以及7.5个月时的软组织裂隙程度。研究结果显示，所有治疗组均有骨形成的影像学和组织学证据，与单独使用胶原基质相比，Bio-Oss和每克胶原基质含2.5毫克骨形成蛋白-1的治疗组在软组织裂隙深度和残余侧壁缺损表面积方面均有统计学意义的显著降低。这些结果表明，Bio-Oss和每克胶原基质含2.5毫克骨形成蛋白-1能有效刺激上颌窦内的骨形成。
