Madhani H D, Fink G R
Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142, USA.
Trends Cell Biol. 1998 Sep;8(9):348-53. doi: 10.1016/s0962-8924(98)01298-7.
Many members of the fungal kingdom have a distinguishing feature, dimorphism, which is the ability to switch between two morphological forms: a cellular yeast form and a multicellular invasive filamentous form. At least three pathways are involved in regulating the transition between these two forms in the budding yeast Saccharomyces cerevisiae, and evidence is now emerging that homologous signalling modules are involved in regulating filament formation and virulence in a range of human and plant fungal pathogens. Strikingly, components used to signal sexual differentiation in the response to mating pheromones are often reutilized to regulate dimorphic development, suggesting an ancient link between these processes.
真菌界的许多成员都有一个显著特征，即二态性，也就是能够在两种形态之间转换：细胞酵母形态和多细胞侵袭性丝状形态。在出芽酵母酿酒酵母中，至少有三条途径参与调节这两种形态之间的转变，现在有证据表明，同源信号模块参与调节一系列人类和植物真菌病原体中的丝状形成和毒力。引人注目的是，用于在对交配信息素的反应中信号性分化的成分常常被重新用于调节二态发育，这表明这些过程之间存在古老的联系。
