Rachman I M, Unnerstall J R, Pfaff D W, Cohen R S
Department of Anatomy and Cell Biology (M/C 512), University of Illinois at Chicago, 808 South Wood Street, Chicago, IL 60612, USA.
Brain Res Mol Brain Res. 1998 Aug 15;59(1):105-8. doi: 10.1016/s0169-328x(98)00131-4.
Short-term estrogenic regulation of neuronal nitric oxide synthase (nNOS) mRNA in the ventrolateral subdivision of the ventromedial nucleus (VLVMN), an area central to lordosis, was demonstrated using in situ hybridization. Estrogen-treated animals showed a significantly greater signal in the VLVMN, but not the arcuate or supraoptic nuclei, compared to ovariectomized controls. Neuronal NOS may be involved in early actions of estrogen in the VLVMN.
利用原位杂交技术证实，雌激素对腹内侧核腹外侧亚区（VLVMN）（一个与脊柱前凸相关的关键区域）的神经元型一氧化氮合酶（nNOS）mRNA具有短期调控作用。与去卵巢对照组相比，经雌激素处理的动物在VLVMN中显示出明显更强的信号，但在弓状核或视上核中则没有。神经元型一氧化氮合酶可能参与了雌激素在VLVMN中的早期作用。
