Wegiel J, Wiśniewski H M, Dziewiatkowski J, Tarnawski M, Kozielski R, Trenkner E, Wiktor-Jedrzejczak W
New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA.
Brain Res. 1998 Aug 31;804(1):135-9. doi: 10.1016/s0006-8993(98)00618-0.
The numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37% in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for macrophages. Moreover, microglia in the frontal cortex of the op/op mice are smaller and have shorter cytoplasmic processes compared to control mice. Study suggests that CSF-1 plays a role in vivo in the formation and maturation of microglia and has little or no effect on perivascular cells.
在op位点发生突变且完全缺乏集落刺激因子-1（CSF-1，巨噬细胞的主要生长因子）的小鼠中，胼胝体中微胶质细胞的数量密度降低了47%，顶叶皮质中降低了37%，额叶皮质中降低了34%。此外，与对照小鼠相比，op/op小鼠额叶皮质中的小胶质细胞更小，细胞质突起更短。研究表明，CSF-1在体内对小胶质细胞的形成和成熟起作用，对血管周围细胞几乎没有影响。
