Maren S
Department of Psychology and Neuroscience Program, University of Michigan, 525 E. University Avenue, Ann Arbor, MI 48109-1109, USA.
Brain Res. 1998 Aug 31;804(1):155-8. doi: 10.1016/s0006-8993(98)00668-4.
The effect of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase (nNOS) inhibitor, on contextual fear conditioning in rats was examined. Systemic administration of 7-NI did not affect the acquisition of contextual fear (measured as freezing), but it did reduce locomotor activity and cause a corresponding increase in the expression of contextual freezing. It is concluded that nNOS activity is not required for either the acquisition or expression of contextual fear conditioning.
