短暂电刺激穿通路径后出现的自维持性癫痫持续状态。
Self-sustaining status epilepticus after brief electrical stimulation of the perforant path.
作者信息
Mazarati A M, Wasterlain C G, Sankar R, Shin D
机构信息
Veteran Administration Medical Center, Neurology Service, UCLA School of Medicine, Sepulveda, USA.
出版信息
Brain Res. 1998 Aug 10;801(1-2):251-3. doi: 10.1016/s0006-8993(98)00606-4.
We examined the duration of intermittent perforant path stimulation (PPS) needed to induce self-sustaining status epilepticus (SSSE) in rats. Seven-minute PPS did not induce SSSE. Some rats receiving 15 min and all animals after 30 min PPS developed SSSE that continued for hours. The animals killed 3 days after SSSE showed extensive neuronal damage. Those which were allowed to survive for 6 weeks after SSSE displayed spontaneous seizures.
我们研究了在大鼠中诱导自持续癫痫持续状态（SSSE）所需的间歇性穿通通路刺激（PPS）的持续时间。7分钟的PPS未诱导出SSSE。一些接受15分钟PPS的大鼠以及所有接受30分钟PPS后的动物都出现了持续数小时的SSSE。在SSSE发生3天后处死的动物显示出广泛的神经元损伤。那些在SSSE后存活6周的动物出现了自发性癫痫发作。
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