Qian Z M, Wang Q
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Brain Res Brain Res Rev. 1998 Aug;27(3):257-67. doi: 10.1016/s0165-0173(98)00012-5.
New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism. According to these findings, disruption in the expression of these proteins in the brain is probably one of the important causes of the altered brain iron metabolism in age-related neurodegenerative diseases, including Parkinson's Disease, Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis. Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.
过去3年中获得的关于乳铁蛋白受体（LfR）、黑素转铁蛋白（MTf）、铜蓝蛋白（CP）和二价阳离子转运体1（DCT1）在脑铁转运中的作用的新发现，是脑铁代谢生理和病理生理学领域的重要进展。根据这些发现，这些蛋白质在脑中表达的破坏可能是包括帕金森病、阿尔茨海默病、亨廷顿病和肌萎缩侧索硬化症在内的与年龄相关的神经退行性疾病中脑铁代谢改变的重要原因之一。进一步研究LfR、MTf和DCT1在不同类型脑细胞摄取铁中的作用以及CP在铁流出中的作用，以及这些蛋白质在脑中的表达调控机制，对于阐明神经退行性疾病中脑铁过度积累和神经元死亡的原因至关重要。
