大鼠视网膜中P2X受体的基因表达。
Gene expression of the P2X receptors in the rat retina.
作者信息
Brändle U, Guenther E, Irrle C, Wheeler-Schilling T H
机构信息
Department of Otolaryngology, University of Tübingen, Roentgenweg 11, 72076, Tübingen, Germany.
出版信息
Brain Res Mol Brain Res. 1998 Aug 31;59(2):269-72. doi: 10.1016/s0169-328x(98)00159-4.
Molecular-biological methods were used to demonstrate the expression of six P2X receptor subunits (P2X1-P2X6) in retina and choroid. Despite the considerable evidence for signalling by extracellular nucleotides in other sensory systems, few studies have been undertaken in the eye. RT-PCR for the detection of P2X subunit mRNA in the rat of different postnatal developmental stages (P23-P210) revealed the presence of P2X2 and P2X4 mRNA in the retina and choroid; P2X3, and P2X5 were detected only in the retina. There was no evidence for P2X1 and P2X6 mRNA in the ocular tissue under investigation. Our data suggest that extracellular ATP may have influences on visual processing.
采用分子生物学方法来证明六种P2X受体亚基（P2X1 - P2X6）在视网膜和脉络膜中的表达。尽管在其他感觉系统中细胞外核苷酸信号传导的证据相当充分，但在眼睛方面进行的研究却很少。通过逆转录聚合酶链反应（RT-PCR）检测不同出生后发育阶段（P23 - P210）大鼠的P2X亚基mRNA，结果显示视网膜和脉络膜中存在P2X2和P2X4 mRNA；仅在视网膜中检测到P2X3和P2X5。在所研究的眼组织中未发现P2X1和P2X6 mRNA的证据。我们的数据表明细胞外ATP可能对视觉处理有影响。
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