Kesl L D, Engen R L
Department of Physiology and Pharmacology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.
J Appl Physiol (1985). 1998 Sep;85(3):1037-43. doi: 10.1152/jappl.1998.85.3.1037.
This investigation examined the effects of NaHCO3 loading on lactate concentration ([La]), acid-base balance, and performance for a 603. 5-m sprint task. Ten greyhounds completed a NaHCO3 (300 mg/kg body weight) and control trial in a crossover design. Results are expressed as means +/- SE. Presprint differences (P < 0.05) were found for NaHCO3 vs. control, respectively, for blood pH (7.47 +/- 0.01 vs. 7.42 +/- 0.01), HCO-3 (28.4 +/- 0.4 vs. 23.5 +/- 0.3 meq/l), and base excess (5.0 +/- 0.3 vs. 0.2 +/- 0.3 meq/l). Peak blood [La] increased (P < 0.05) in NaHCO3 vs. control (20.4 +/- 1.6 vs. 16.9 +/- 1.3 mM, respectively). Relative to control, NaHCO3 produced a greater (P < 0.05) reduction in blood base excess (-18.5 +/- 1.4 vs. -14.1 +/- 0.8 meq/l) and HCO-3 (-17.4 +/- 1.2 vs. -12.8 +/- 0.7 meq/l) from presprint to postexercise. Postexercise peak muscle H+ concentration ([H+]) was higher (P < 0.05) in NaHCO3 vs. control (158.8 +/- 8.8 vs. 137.0 +/- 5.3 nM, respectively). Muscle [H+] recovery half-time (7.2 +/- 1.6 vs. 11.3 +/- 1.6 min) and time to predose values (22.2 +/- 2.4 vs. 32.9 +/- 4.0 min) were reduced (P < 0.05) in NaHCO3 vs. control, respectively. No differences were found in blood [H+] or blood [La] recovery curves or performance times. NaHCO3 increased postexercise blood [La] but did not reduce the muscle or blood acid-base disturbance associated with a 603.5-m sprint or significantly affect performance.
本研究考察了碳酸氢钠负荷对603.5米短跑任务中乳酸浓度（[La]）、酸碱平衡及运动表现的影响。十只灵缇犬采用交叉设计完成了一次碳酸氢钠（300毫克/千克体重）试验和一次对照试验。结果以均值±标准误表示。碳酸氢钠组与对照组相比，预跑前血液pH值（7.47±0.01对7.42±0.01）、碳酸氢根（28.4±0.4对23.5±0.3毫当量/升）和碱剩余（5.0±0.3对0.2±0.3毫当量/升）存在显著差异（P<0.05）。碳酸氢钠组与对照组相比，血液[La]峰值升高（P<0.05）（分别为20.4±1.6对16.9±1.3毫摩尔/升）。相对于对照组，碳酸氢钠组从预跑前到运动后血液碱剩余（-18.5±1.4对-14.1±0.8毫当量/升）和碳酸氢根（-17.4±1.2对-12.8±0.7毫当量/升）的降低幅度更大（P<0.05）。运动后肌肉H⁺浓度（[H⁺]）峰值碳酸氢钠组高于对照组（P<0.05）（分别为158.8±8.8对137.0±5.3纳摩尔/升）。碳酸氢钠组与对照组相比，肌肉[H⁺]恢复半衰期（7.2±1.6对11.3±1.6分钟）和恢复到给药前水平的时间（22.2±2.4对32.9±4.0分钟）均缩短（P<0.05）。血液[H⁺]或血液[La]恢复曲线及运动表现时间未发现差异。碳酸氢钠增加了运动后血液[La]，但并未减轻603.5米短跑相关的肌肉或血液酸碱紊乱，也未显著影响运动表现。
