Gibson Brandon M, Needham Karen Wiedenfeld, Kaiser Brendan W, Wilkins Brad W, Minson Christopher T, Halliwill John R
Department of Human Physiology, University of Oregon, Eugene, OR, United States.
Front Physiol. 2023 Mar 7;14:1142567. doi: 10.3389/fphys.2023.1142567. eCollection 2023.
Oral bicarbonate loading improves the buffering of metabolic acidosis and may improve exercise performance but can also result in gastric distress. Momentous' PR Lotion contains a novel composition intended to provide a transdermal delivery vehicle for sodium bicarbonate which could allow the same ergogenic effect without the gastric distress. The present study explored the effect of transdermal delivery of sodium bicarbonate in a resting condition. We measured the pH from intramuscular dialysate, microdialysis, of the during a 2 h application of PR Lotion (40 g of lotion per leg) in 9 subjects (3 women, 6 men). Venous blood samples were obtained for serum pH before and after application. A placebo time control was also performed in 4 subjects (2 women, 2 men). We hypothesized that PR Lotion application would increase pH of intramuscular dialysate. PR Lotion resulted in a rise in pH of 0.13 ± 0.04 units ( < 0.05), which translates to a 28% reduction in [H]. Increases in serum pH were smaller (∼9%) yet consistent ( < 0.05). In contrast, placebo time control pH tended to decrease ( = 0.08). The effect of PR Lotion on pH tended to correlate with the dose per kg body weight of each individual ( = 0.70, 0.08). These observations support the idea of transdermal bicarbonate delivery impacting pH buffering both systemically and intramuscularly. Further work investigating these potential benefits in an exercising model would be critical to establishing PR Lotion's utility as an ergogenic aid.
口服碳酸氢盐负荷可改善代谢性酸中毒的缓冲能力，可能提高运动表现，但也可能导致胃部不适。Momentous公司的PR乳液含有一种新型成分，旨在为碳酸氢钠提供一种透皮给药载体，从而在不引起胃部不适的情况下达到相同的促力效果。本研究探讨了在静息状态下碳酸氢钠透皮给药的效果。我们对9名受试者（3名女性，6名男性）每条腿涂抹PR乳液（40克乳液）2小时期间，通过微透析法测量了肌肉内透析液的pH值。在涂抹前后采集静脉血样本测定血清pH值。还对4名受试者（2名女性，2名男性）进行了安慰剂时间对照。我们假设涂抹PR乳液会提高肌肉内透析液的pH值。PR乳液使pH值升高了0.13±0.04个单位（P<0.05），这相当于[H]降低了28%。血清pH值的升高幅度较小（约9%）但具有一致性（P<0.05）。相比之下，安慰剂时间对照的pH值有下降趋势（P = 0.08）。PR乳液对pH值的影响与每个个体每千克体重的剂量呈正相关趋势（r = 0.70，P = 0.08）。这些观察结果支持了碳酸氢钠透皮给药会对全身和肌肉内的pH缓冲产生影响这一观点。在运动模型中进一步研究这些潜在益处对于确定PR乳液作为一种促力辅助剂的效用至关重要。
