Granier P L, Dubouchaud H, Mercier B M, Mercier J G, Ahmaidi S, Préfaut C G
Laboratoire de Physiologie des Interactions, Hôpital Arnaud de Villeneuve, Montpellier, France.
Med Sci Sports Exerc. 1996 Jun;28(6):692-7. doi: 10.1097/00005768-199606000-00008.
We investigated NaHCO3 infusion effects on plasma lactate removal by forearm muscles and performance during intensive leg exercise. Seven subjects performed the force-velocity (FV) test with placebo and NaHCO3 (2 mEq.min-1) with a double-blind crossover protocol. Blood samples for arterial ([LA]A) and venous ([LA]V) lactate determinations were taken 1) at rest before infusion, and 2, 6, 10, 14, 18, and 22 min following its start; and 2) at the end of each exercise bout. The arteriovenous difference ([LA]A-V) was determined for each sampling. NaHCO3 significantly increased arterial bicarbonate concentration and pH during rest (P < 0.001; P < 0.001) and the FV test (P < 0.001; P < 0.05). During the test, [LA]A and [LA]V were significantly higher with NaHCO3 (P < 0.05, P < 0.001). At test onset, [LA]A-V became positive and increased until the braking force of 6 kg, with NaHCO3 and placebo, with values significantly lower for NaHCO3 (P < 0.001). Peak anaerobic power (Wanae, peak) and the corresponding braking force (Fmax) were also determined. Fmax was significantly increased with NaHCO3 (P < 0.001). In conclusion, the increasing rise in [LA]A and [LA]V induced by NaHCO3 may be partly explained by a decreased rate of lactate uptake by forearm skeletal muscles. NaHCO3 did not improve Wanae, peak, but improved Fmax, thus increasing FV duration.
我们研究了输注碳酸氢钠对前臂肌肉清除血浆乳酸的影响以及高强度腿部运动期间的运动表现。七名受试者采用双盲交叉方案，分别在服用安慰剂和碳酸氢钠（2 毫当量·分钟⁻¹）的情况下进行力-速度（FV）测试。在输注前静息状态下、输注开始后的 2、6、10、14、18 和 22 分钟以及每次运动回合结束时采集动脉血（[LA]A）和静脉血（[LA]V）样本用于测定乳酸。计算每次采样时的动静脉差值（[LA]A-V）。碳酸氢钠显著提高了静息状态下（P < 0.001；P < 0.001）和 FV 测试期间（P < 0.001；P < 0.05）的动脉碳酸氢盐浓度和 pH 值。在测试期间，服用碳酸氢钠时[LA]A 和[LA]V 显著更高（P < 0.05，P < 0.001）。在测试开始时，服用碳酸氢钠和安慰剂时，[LA]A-V 变为正值并一直增加到 6 千克制动力，服用碳酸氢钠时的值显著更低（P < 0.001）。还测定了峰值无氧功率（Wanae，peak）和相应的制动力（Fmax）。服用碳酸氢钠时 Fmax 显著增加（P < 0.001）。总之，碳酸氢钠引起的[LA]A 和[LA]V 的升高增加可能部分是由于前臂骨骼肌摄取乳酸的速率降低所致。碳酸氢钠并未改善峰值无氧功率（Wanae，peak），但改善了 Fmax，从而延长了 FV 持续时间。
