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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Brock J A, McLachlan E M, Belmonte C

Prince of Wales Medical Research Institute, High Street, Randwick, NSW 2031, Australia.

J Physiol. 1998 Oct 1;512 ( Pt 1)(Pt 1):211-7. doi: 10.1111/j.1469-7793.1998.211bf.x.

Extracellular recording techniques have been used to study nerve impulses in single sensory nerve terminals in guinea-pig cornea isolated in vitro. 2. Nerve impulses occurred spontaneously and were evoked by electrical stimulation of the ciliary nerves. 3. The nerve impulses were identified as originating in polymodal receptors, mechano-receptors or 'cold' receptors. All three types are believed to be nociceptors. 4. Tetrodotoxin (TTX, 1 microM) blocked nerve impulses evoked by electrical stimulation of the ciliary nerves. However, ongoing and/or naturally evoked nerve impulses persisted in the presence of TTX in all three types of receptors. Lignocaine (lidocaine; 1 mM) blocked all electrical activity. 5. TTX-resistant sodium channels therefore play a major role in generating the action potentials that signal pain to the brain.

细胞外记录技术已被用于研究体外分离的豚鼠角膜单个感觉神经末梢中的神经冲动。2. 神经冲动自发出现，并可通过睫状神经的电刺激诱发。3. 这些神经冲动被确定起源于多模式感受器、机械感受器或“冷”感受器。所有这三种类型都被认为是伤害感受器。4. 河豚毒素（TTX，1微摩尔）阻断了睫状神经电刺激诱发的神经冲动。然而，在所有三种类型的感受器中，TTX存在时持续的和/或自然诱发的神经冲动仍然存在。利多卡因（1毫摩尔）阻断了所有电活动。5. 因此，对河豚毒素有抗性的钠通道在产生向大脑发出疼痛信号的动作电位中起主要作用。

Brock J A, McLachlan E M, Belmonte C

Prince of Wales Medical Research Institute, High Street, Randwick, NSW 2031, Australia.

J Physiol. 1998 Oct 1;512 ( Pt 1)(Pt 1):211-7. doi: 10.1111/j.1469-7793.1998.211bf.x.

Extracellular recording techniques have been used to study nerve impulses in single sensory nerve terminals in guinea-pig cornea isolated in vitro. 2. Nerve impulses occurred spontaneously and were evoked by electrical stimulation of the ciliary nerves. 3. The nerve impulses were identified as originating in polymodal receptors, mechano-receptors or 'cold' receptors. All three types are believed to be nociceptors. 4. Tetrodotoxin (TTX, 1 microM) blocked nerve impulses evoked by electrical stimulation of the ciliary nerves. However, ongoing and/or naturally evoked nerve impulses persisted in the presence of TTX in all three types of receptors. Lignocaine (lidocaine; 1 mM) blocked all electrical activity. 5. TTX-resistant sodium channels therefore play a major role in generating the action potentials that signal pain to the brain.

细胞外记录技术已被用于研究体外分离的豚鼠角膜单个感觉神经末梢中的神经冲动。2. 神经冲动自发出现，并可通过睫状神经的电刺激诱发。3. 这些神经冲动被确定起源于多模式感受器、机械感受器或“冷”感受器。所有这三种类型都被认为是伤害感受器。4. 河豚毒素（TTX，1微摩尔）阻断了睫状神经电刺激诱发的神经冲动。然而，在所有三种类型的感受器中，TTX存在时持续的和/或自然诱发的神经冲动仍然存在。利多卡因（1毫摩尔）阻断了所有电活动。5. 因此，对河豚毒素有抗性的钠通道在产生向大脑发出疼痛信号的动作电位中起主要作用。