前列腺素E2：对嗜铬细胞瘤和肾上腺髓质儿茶酚胺释放的相反作用。

PGE2: opposite effect on catecholamine release from phaeochromocytoma and adrenal medulla.

作者信息

Gutman Y, Boonyaviroj P

出版信息

Prostaglandins. 1976 Oct;12(4):487-91. doi: 10.1016/0090-6980(76)90029-0.

DOI:10.1016/0090-6980(76)90029-0

Abstract

The effect of PGE2 on catecholamine release from human adrenal medulla and phaechromocytoma was studied in slices incubated in vitro. In each of 3 normal human adrenal medullae PGE2 (10(-7) M) caused a significant inhibition of the release of catecholamines in in vitro incubation. In each of 3 phaechromocytomas studied PGE2 (10(-7) M) caused a significant increase of catecholamine release in in-vitro incubation. The possible relevance of this mechanism to the regulation of catecholamine release in phaeochromocytoma is discussed.

摘要

在体外培养的切片中研究了前列腺素E2（PGE2）对人肾上腺髓质和嗜铬细胞瘤中儿茶酚胺释放的影响。在3个正常的人肾上腺髓质中，PGE2（10^-7 M）在体外培养时均显著抑制了儿茶酚胺的释放。在所研究的3个嗜铬细胞瘤中，PGE2（10^-7 M）在体外培养时均显著增加了儿茶酚胺的释放。讨论了该机制与嗜铬细胞瘤中儿茶酚胺释放调节的可能相关性。

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PGE2: opposite effect on catecholamine release from phaeochromocytoma and adrenal medulla.前列腺素E2：对嗜铬细胞瘤和肾上腺髓质儿茶酚胺释放的相反作用。

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引用本文的文献

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Reversal of prostaglandin E2 effect on adrenal catecholamine release after hypophysectomy.垂体切除术后前列腺素E2对肾上腺儿茶酚胺释放作用的逆转

Br J Pharmacol. 1977 Jul;60(3):477-8. doi: 10.1111/j.1476-5381.1977.tb07525.x.

2

Opposite effect of PGE2 on cAMP levels in human adrenal medulla and pheochromocytoma.前列腺素E2对人肾上腺髓质和嗜铬细胞瘤中环磷酸腺苷水平的相反作用。

Experientia. 1977 Aug 15;33(8):1113-4. doi: 10.1007/BF01946002.

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