前列腺素E2对人肾上腺髓质和嗜铬细胞瘤中环磷酸腺苷水平的相反作用。
Opposite effect of PGE2 on cAMP levels in human adrenal medulla and pheochromocytoma.
作者信息
Boonyaviroj P, Gutman Y
出版信息
Experientia. 1977 Aug 15;33(8):1113-4. doi: 10.1007/BF01946002.
PMID:196898
Abstract
PGE2 (10(-7) M) caused increased cAMP accumlation in 5 pheochromocytomas, while in 3 human adrenal medullae PGE2 caused a significant decrease of cAMP level on incubating slices in vitro. This finding is discussed in relation to the opposite effect of PGE2 on catecholamine release from human medulla and pheochromocytoma slices in vitro.
摘要
前列腺素E2（10⁻⁷ M）可使5例嗜铬细胞瘤中的环磷酸腺苷（cAMP）积累增加，而在3例人肾上腺髓质中，体外孵育切片时前列腺素E2可使cAMP水平显著降低。结合前列腺素E2对体外人髓质和嗜铬细胞瘤切片儿茶酚胺释放的相反作用，对这一发现进行了讨论。
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