Srivastava R N, Mayekar G, Anand R, Choudhry V P, Ghai O P, Tandon H D
Arch Dis Child. 1975 Aug;50(8):626-30. doi: 10.1136/adc.50.8.626.
A clinicopathological study of 206 Indian children with nephrotic syndrome showed a primary renal cause in 195 (96%), of which 77% were boys. In 126 children (96 boys, 30 girls) onset of the disorder occurred before the age of 5 years. Renal biopsy showed minimal lesions in 150 patients (77%); in 85 of these biopsy was done 3 months to 16 years after onset of the nephrotic syndrome. Significant renal histological abnormalities in 45 cases were labelled as mesangiocapillary 8, mesangioproliferative 4, proliferative with extensive crescents 2, membranous 3, focal segmental glomerulosclerosis 9, focal global glomerulosclerosis 2, advanced nonspecific 8, and mild proliferative 9. Nephritic manifestations were mainly associated with significant renal lesions, which were more frequently encountered when the onset of disease was after the age of 5 years. Clearance of proteinuria with corticosteroid therapy was practically confined to patients with minimal or mild renal histological changes. Our findings suggest that the pattern of idiopathic nephrotic syndrome in Indian children is similar to that reported from Western countries.
一项对206名印度肾病综合征患儿的临床病理研究表明，195名（96%）患儿有原发性肾脏病因，其中77%为男孩。126名患儿（96名男孩，30名女孩）在5岁前发病。肾活检显示150例患者（77%）为微小病变；其中85例在肾病综合征发病后3个月至16年进行了活检。45例有明显肾脏组织学异常，分别标记为：系膜毛细血管性8例、系膜增生性4例、伴有广泛新月体形成的增生性2例、膜性3例、局灶节段性肾小球硬化9例、局灶球性肾小球硬化2例、晚期非特异性8例、轻度增生性9例。肾炎表现主要与明显的肾脏病变相关，当发病年龄在5岁以后时更常出现。糖皮质激素治疗使蛋白尿清除实际上仅限于肾脏组织学改变为微小或轻度的患者。我们的研究结果表明，印度儿童特发性肾病综合征的模式与西方国家报道的相似。
