Bodaghi E, Vazirian S, Abtahi M, Honarmand M T, Madani A, Zia Shamsa A M
Nephrology Division, Children's Medical Center, Teheran, Iran.
Pediatr Nephrol. 1989 Apr;3(2):213-7; discussion 221. doi: 10.1007/BF00852913.
A total of 411 children, aged from 0.3 to 18 years, suffering from glomerular diseases, were studied by renal biopsy between 1976 and 1985. The clinical presentation included nephrotic syndrome (79% of cases), renal failure (43%), and arterial hypertension (38%). In all, 177 cases presented with primary nephrotic syndrome; all had complicated courses and most were either corticosteroid-dependent or -resistant. Only 26.6% had minimal change disease on renal biopsy; 56.5% had focal-segmental sclerosis; and immunofluorescent deposits were observed in half of the group. Acute poststreptococcal (36 cases), mesangiocapillary (80 cases), and lupus (34 cases) glomerulonephritis occurred frequently; IgA glomerulopathy (10 cases) and haemolytic uraemic syndrome (6 cases) were uncommon. Glomerular crescents were observed in 71 cases. These observations illustrate the types of glomerular diseases seen in Iranian children.
1976年至1985年间，对411名年龄在0.3至18岁之间患有肾小球疾病的儿童进行了肾活检研究。临床表现包括肾病综合征（79%的病例）、肾衰竭（43%）和动脉高血压（38%）。共有177例表现为原发性肾病综合征；所有病例病程均复杂，大多数对皮质类固醇依赖或耐药。肾活检显示仅26.6%为微小病变性肾病；56.5%为局灶节段性硬化；该组半数观察到免疫荧光沉积物。急性链球菌感染后肾小球肾炎（36例）、系膜毛细血管性肾小球肾炎（80例）和狼疮性肾小球肾炎（34例）频繁发生；IgA肾病（10例）和溶血尿毒综合征（6例）不常见。71例观察到肾小球新月体形成。这些观察结果说明了伊朗儿童中所见的肾小球疾病类型。
