Chatterjee A
Prostaglandins. 1976 Oct;12(4):525-34. doi: 10.1016/0090-6980(76)90033-2.
A comparative assessment of the efficacy of prolactin or HCG in reversing the luteolytic property of a single dose (2.0 mg/kg) of PGF2a was conducted in pregnant (day 10) rats. It was found that prolactin maintained pregnancy in 90% of the test animals. HCG though found to maintain pregnancy in 70% of the PGF2a-treated pregnants, the fetal survival rate was, however, recorded to be 62% against the control value of 98%. Conversely, prolactin replacement maintained the fetal survival rate as high as 93.4%. Moreover, the growth of the fetuses, placentae and corpus luteum in the pregnants having prolactin in conjunction with PGF2a was also found to be greater compared to the animals which had a combined regimen of PGF2a and HCG, but identical to controls. On the other hand, similar combined regimen when applied to hysterectomized pregnant rats, it was observed that though the vaginal diestrus was maintained by the prolactin or HCG in the presence of PGF2a, the prolactin regimen was found to be superb compared to HCG in the maintenance of luteal weight and functional activity. It was concluded that the antifertility effect of PGF2a in the rat is primarily the consequence of luteolysis and prolactin seems to be a much more appropriate hormonal replacement compared to HCG, a long-acting LH, in antagonizing the luteolytic property of PGF2a.
在怀孕（第10天）大鼠中，对催乳素或人绒毛膜促性腺激素（HCG）逆转单剂量（2.0毫克/千克）前列腺素F2α（PGF2α）黄体溶解特性的功效进行了比较评估。结果发现，催乳素使90%的受试动物维持妊娠。虽然HCG使70%接受PGF2α处理的怀孕大鼠维持妊娠，但其胎儿存活率为62%，而对照值为98%。相反，催乳素替代使胎儿存活率高达93.4%。此外，与接受PGF2α和HCG联合方案的动物相比，同时接受催乳素和PGF2α的怀孕大鼠的胎儿、胎盘和黄体生长也更大，但与对照组相同。另一方面，当将类似的联合方案应用于子宫切除的怀孕大鼠时，观察到虽然在PGF2α存在的情况下，催乳素或HCG维持了阴道间情期，但在维持黄体重量和功能活性方面，催乳素方案比HCG更好。得出的结论是，PGF2α在大鼠中的抗生育作用主要是黄体溶解的结果，与长效促黄体生成素HCG相比，催乳素似乎是对抗PGF2α黄体溶解特性更合适的激素替代物。
