Leader A, Bygdeman M, Eneroth P, Lundström V, Martin J N
Prostaglandins. 1976 Oct;12(4):631-7. doi: 10.1016/0090-6980(76)90042-3.
15(S)15-methyl PGF2alpha methyl ester was self-administered vaginally to terminate pregnancy in 42 women in the 8-9th week of gestation. Ten patients received a total of 6 mg of the compound over 15 hours (Group I) while the remaining 32 patients received 5.5 mg of the prostaglandin compound during a shorter period of time or 9 hours (Group II). If parts of the conceptus were expelled during treatment, surgical intervention was excluded. All patients were followed closely after treatment with repeated serum HCG assays and clinical examinations. All patients in Group II and eight out of ten patients in Group I aborted following treatment. In 33 of the 42 patients, the serum HCG levels and the clinical course following the expulsion of the conceptus indicated that abortion was complete. Gastro-intestinal side effects were minimal if anti-diarrheic agents were given prophylactically. The incidence of uterine pain was variable but could in most cases be controlled by oral or rectal administration of analgetics. The results of this study suggest that the use of this compound for termination of pregnancy may be safely extended through the 9th week of gestation and in certain cases be an alternative to the normal operative procedure.
15（S）-15-甲基前列腺素F2α甲酯经阴道自我给药，用于终止42例妊娠8 - 9周妇女的妊娠。10例患者在15小时内共接受6毫克该化合物（第一组），其余32例患者在较短时间即9小时内接受5.5毫克前列腺素化合物（第二组）。若在治疗期间有部分妊娠产物排出，则排除手术干预。治疗后对所有患者进行密切随访，反复检测血清人绒毛膜促性腺激素（HCG）并进行临床检查。第二组所有患者及第一组10例中的8例在治疗后流产。42例患者中有33例，其血清HCG水平及妊娠产物排出后的临床过程表明流产完全。若预防性给予止泻药，胃肠道副作用极小。子宫疼痛的发生率各不相同，但在大多数情况下可通过口服或直肠给予镇痛药加以控制。本研究结果表明，使用该化合物终止妊娠在妊娠第9周前可安全进行，在某些情况下可替代常规手术操作。
