Karim S M, Choo H T, Cheng P
Prostaglandins. 1975 Apr;9(4):631-8. doi: 10.1016/0090-6980(75)90069-6.
Dilatation of the cervix with prostaglandin analogues prior to vaginal termination of pregnancy was attempted in 125 nulliparous women in the first trimester of pregnancy. The patients were divided into five groups (25 in each group) and given a single extra-amniotic dose of one of the following prostaglandin analogues 14-16 hours prior to the evacuation of the uterus by vacuum aspiration. (Group A) 15 (S) 15 methyl PGE2 (free acid); (Group B) 15 (S) 15 methyl PGE2 methyl ester; (Group C) 15 (S) 15 methyl PGF2alpha (free acid); (Group D) 15 (S) 15 methyl PGF2alpha methyl ester and(Group E) a mixture of 15 (S) 15 methyl PGE2methyl ester and 15 (S) 15 methyl PGF2alpha methyl ester. Evacuation of the uterus without mechanical dilatation of the cervix was possible in 111 (90%) of the patients. In an additional 10 patients (8%) there was some degree of cervical dilatation and further mechanical dilatation could be performed easily. With the combination of 15 (S) 15 methyl PGE2 methyl ester and 15 (S) 15 methyl PGF2alpha methyl ester the incidence of gastrointestinal side effects and pyrexia were considerably reduced.
对125例妊娠早期的未生育女性尝试在经阴道终止妊娠前用前列腺素类似物扩张宫颈。将患者分为五组（每组25例），在通过真空吸引排空子宫前14 - 16小时经羊膜外给予下列前列腺素类似物之一的单次剂量。（A组）15（S）15 - 甲基PGE2（游离酸）；（B组）15（S）15 - 甲基PGE2甲酯；（C组）15（S）15 - 甲基PGF2α（游离酸）；（D组）15（S）15 - 甲基PGF2α甲酯；（E组）15（S）15 - 甲基PGE2甲酯和15（S）15 - 甲基PGF2α甲酯的混合物。111例（90%）患者在未机械扩张宫颈的情况下成功排空子宫。另外10例患者（8%）宫颈有一定程度的扩张，且可轻松进行进一步的机械扩张。使用15（S）15 - 甲基PGE2甲酯和15（S）15 - 甲基PGF2α甲酯的组合，胃肠道副作用和发热的发生率显著降低。
