大豆异黄酮对人前列腺癌细胞系LNCaP细胞生长和凋亡的影响。
Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP.
作者信息
Onozawa M, Fukuda K, Ohtani M, Akaza H, Sugimura T, Wakabayashi K
机构信息
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan.
出版信息
Jpn J Clin Oncol. 1998 Jun;28(6):360-3. doi: 10.1093/jjco/28.6.360.
BACKGROUND
Epidemiological studies have suggested that soybean isoflavones are associated with a lower risk of prostate cancer. However, the mechanisms of prostate cancer prevention by soybean isoflavones have yet to be fully clarified.
METHODS
Two soybean isoflavones (genistein and daidzein) and their glucosides (genistin and daidzin) were tested for their effects on cell growth and apoptosis of the LNCaP human prostatic cancer cell line.
RESULTS
Among these isoflavones, genistein was found to inhibit the growth of LNCaP most effectively, with an IC50 value of 40 microM. The inhibition of cell growth by genistein was accompanied by the suppression of DNA synthesis and the induction of apoptosis. Expression of prostate-specific antigen (PSA) in LNCaP was also significantly reduced by the treatment with genistein.
CONCLUSIONS
The results suggest that genistein might primarily influence human prostate cancer development by reducing tumor growth.
背景
流行病学研究表明，大豆异黄酮与较低的前列腺癌风险相关。然而，大豆异黄酮预防前列腺癌的机制尚未完全阐明。
方法
测试了两种大豆异黄酮（染料木黄酮和大豆苷元）及其糖苷（染料木苷和大豆苷）对LNCaP人前列腺癌细胞系细胞生长和凋亡的影响。
结果
在这些异黄酮中，发现染料木黄酮对LNCaP生长的抑制作用最有效，IC50值为40微摩尔。染料木黄酮对细胞生长的抑制伴随着DNA合成的抑制和凋亡的诱导。用染料木黄酮处理后，LNCaP中前列腺特异性抗原（PSA）的表达也显著降低。
结论
结果表明，染料木黄酮可能主要通过减少肿瘤生长来影响人类前列腺癌的发展。
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