佛波酯衍生物对蛋白激酶C同工酶的光亲和标记

Photoaffinity labeling of PKC isozymes by phorbol ester derivatives.

作者信息

Uotsu K, Sodeoka M, Shibasaki M

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.

出版信息

Bioorg Med Chem. 1998 Jul;6(7):1117-26. doi: 10.1016/s0968-0896(98)00068-6.

DOI:10.1016/s0968-0896(98)00068-6

PMID:9730248

Abstract

Photoaffinity probes PPDA and PPTD, which have diazoacetyl and trifluorodiazopropionyl group at C-13 position in phorbol, respectively, were synthesized. Photoaffinity labeling of protein kinase C isozymes by both the probes resulted in specific cross-linking.

摘要

合成了光亲和探针PPDA和PPTD，它们在佛波醇的C-13位分别具有重氮乙酰基和三氟二氮丙酰基。这两种探针对蛋白激酶C同工酶进行光亲和标记均导致特异性交联。