Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.
Chem Commun (Camb). 2018 Feb 8;54(13):1591-1594. doi: 10.1039/c7cc07391g.
Photopharmaceuticals can, in principle, be created by linking photoswitchable moieties to bioactive molecules. However, a general strategy for converting a therapeutic agent into its photoswitchable version is not currently available. Herein we propose a generalizable, modular approach for obtaining light controllable bioactive agents by modifying the scaffold of a protein affinity reagent using an azobenzene photoswitch.
光致药物原则上可以通过将光致开关部分与生物活性分子连接来制备。然而，目前还没有将治疗剂转化为其光致开关形式的通用策略。在此，我们提出了一种可推广的、模块化的方法，通过使用偶氮苯光开关修饰蛋白质亲和试剂的支架来获得光控生物活性试剂。
