Naz R K, Evans L, Armstrong J S, Sikka S C
Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43699-0008, USA.
Arch Androl. 1998 Sep-Oct;41(2):91-6. doi: 10.3109/01485019808987950.
The interleukin (IL)-12 levels and the superoxide dismutase (SOD) activity were determined in the seminal plasma of fertile and infertile men with or without leukocytospermia by ELISA. The IL-12 levels differed significantly among the fertile and infertile groups, with the infertile groups showing lower levels that were not modulated by leukocytospermia. The SOD activity did not differ significantly among the fertile and infertile groups and was not correlated with the IL-12 levels. The positive correlation with sperm concentration suggests that IL-12 may have a direct or indirect role in male fertility/infertility and that its levels are not modulated by the presence of leukocytes in the semen.
通过酶联免疫吸附测定法（ELISA）测定了有或无白细胞精子症的生育男性和不育男性精液中的白细胞介素（IL）-12水平和超氧化物歧化酶（SOD）活性。生育组和不育组之间的IL-12水平存在显著差异，不育组的水平较低，且不受白细胞精子症的调节。生育组和不育组之间的SOD活性无显著差异，且与IL-12水平无关。与精子浓度的正相关表明，IL-12可能在男性生育力/不育症中具有直接或间接作用，并且其水平不受精液中白细胞存在的调节。
