Hybritech Tandem-R检测法与雅培AxSYM检测法在血清前列腺特异性抗原测量方面的可比性。

Comparability of serum prostate-specific antigen measurement between the hybritech Tandem-R and Abbott AxSYM assays.

作者信息

Leewansangtong S, Goktas S, Lepoff R, Holthaus K, Crawford E D

机构信息

Division of Urology, University of Colorado Health Sciences Center, Denver 80262, USA.

出版信息

Urology. 1998 Sep;52(3):467-9. doi: 10.1016/s0090-4295(98)00210-6.

DOI:10.1016/s0090-4295(98)00210-6

PMID:9730462

Abstract

OBJECTIVES

To assess the comparability of the Hybritech Tandem-R and Abbott AxSYM PSA assays in the setting of a hospital laboratory changing methods of PSA assay.

METHODS

A total of 115 serum samples were tested simultaneously with both reagent kits. These include samples from patients evaluated for screening, benign prostatic hyperplasia, and follow-up of prostate cancer.

RESULTS

The outcomes of the Hybritech Tandem-R PSA test ranged from 0.0 to 48.3 ng/mL with a median value of 2.4 ng/mL (mean 3.48, SD 5.46). The outcomes of the Abbott AxSYM PSA test ranged from 0.0 to 49.33 ng/mL with a median of 2.22 ng/mL (mean 3.82, SD 5.59). The outcomes of the two assays were found to be highly correlated by the Pearson correlation coefficient (r = 0.9942). When samples were divided according to PSA levels of 0.0 to less than 2.5, 2.5 to less than 4.0, 4.0 to less than 10.0, and 10.0 to less than 25.0 ng/mL, the outcomes were also highly correlated in all PSA level ranges (r = 0.9619, 0.8094, 0.9167, and 0.9081, respectively).

CONCLUSIONS

The PSA values of the Tandem-R and Abbott AxSYM assays are highly correlated in the PSA level ranges of 0.0 to less than 2.5, 2.5 to less than 4.0, 4.0 to less than 10.0, and 10.0 to less than 25.0 ng/mL.

摘要

目的

在一家医院实验室更换前列腺特异性抗原（PSA）检测方法的背景下，评估Hybritech Tandem - R和雅培AxSYM PSA检测方法的可比性。

方法

使用两种试剂盒同时检测115份血清样本。这些样本包括来自接受筛查、良性前列腺增生评估以及前列腺癌随访的患者。

结果

Hybritech Tandem - R PSA检测结果范围为0.0至48.3 ng/mL，中位数为2.4 ng/mL（均值3.48，标准差5.46）。雅培AxSYM PSA检测结果范围为0.0至49.33 ng/mL，中位数为2.22 ng/mL（均值3.82，标准差5.59）。经皮尔逊相关系数分析发现，两种检测结果高度相关（r = 0.9942）。当根据PSA水平分为0.0至小于2.5、2.5至小于4.0、4.0至小于10.0以及10.0至小于25.0 ng/mL进行分组时，在所有PSA水平范围内结果也高度相关（分别为r = 0.9619、0.8094、0.9167和0.9081）。