Reece E A, Leguizamon G, Homko C
Department of Obstetrics, Gynecology and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
J Matern Fetal Med. 1998 Jul-Aug;7(4):213-6. doi: 10.1002/(SICI)1520-6661(199807/08)7:4<213::AID-MFM11>3.0.CO;2-E.
To evaluate maternal-fetal outcomes in pregnancies complicated by diabetic nephropathy were evaluated. Nephropathy was defined as proteinuria of >300 mg/24, or albuminuria >300 mg/24 hr in the absence of infection. Twenty-seven pregnant women with variable degrees of diabetic nephropathy were included in the study. Prenatal care included stringent metabolic control and management of hypertension. Fetal and maternal outcomes were obtained by medical record review. There were no fetal deaths. One neonatal death occurred in a fetus delivered at 29 weeks gestation. IUGR and major congenital malformations were observed in 9% of the neonates; 26% of the infants were delivered preterm. Chronic hypertension (77%) and preeclampsia (53%) were common maternal complications; 63% of women required delivery by cesarean section. Successful pregnancy outcomes were achieved in >95% of the women in our population. Modern management of the pregnancy complicated by diabetes has substantially improved the outcome of class F/FR diabetic mothers and their infants.
评估了糖尿病肾病合并妊娠的母婴结局。肾病定义为在无感染情况下蛋白尿>300mg/24小时或白蛋白尿>300mg/24小时。27例不同程度糖尿病肾病的孕妇纳入研究。产前护理包括严格的代谢控制和高血压管理。通过病历回顾获得胎儿和母亲的结局。无胎儿死亡。1例孕29周分娩的胎儿发生新生儿死亡。9%的新生儿出现宫内生长受限和严重先天性畸形；26%的婴儿早产。慢性高血压（77%）和先兆子痫（53%）是常见的母亲并发症；63%的女性需要剖宫产分娩。我们研究人群中>95%的女性获得了成功的妊娠结局。糖尿病合并妊娠的现代管理显著改善了F/FR级糖尿病母亲及其婴儿的结局。
