伴有肺转移的非小细胞肺癌患者血清唾液酸化Lewis X-i抗原水平升高。

Elevated serum sialyl Lewis X-i antigen levels in non-small cell lung cancer with lung metastasis.

作者信息

Satoh H, Ishikawa H, Kamma H, Yamashita Y T, Takahashi H, Ohtsuka M, Hasegawa S

机构信息

Department of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Japan.

出版信息

Respiration. 1998;65(4):295-8. doi: 10.1159/000029279.

DOI:10.1159/000029279

PMID:9730796

Abstract

To evaluate the relationship between serum levels of sialyl Lewis X-i antigen and lung metastasis in patients with non-small cell lung cancer (NSCLC), we measured the serum level of the antigen in 299 patients with untreated locally advanced or metastatic NSCLC. Before treatment, serum levels of sialyl Lewis X-i antigen were significantly higher in patients with lung metastasis than in those without lung metastatis (p = 0.0001). Of 201 patients without lung metastasis at the time of primary diagnosis, 121 patients died between July 1987 and December 1995. Serum levels of sialyl Lewis X-i antigen in 21 patients who developed lung metastasis during the period were significantly higher than those in 100 patients who did not develop lung metastasis (p = 0.0171). Our results suggested that sialyl Lewis X-i antigen might be a good indicator for the presence or development of lung metastasis, and it might provide clinical information about the management of patients with NSCLC.

摘要

为评估非小细胞肺癌（NSCLC）患者血清唾液酸化Lewis X-i抗原水平与肺转移之间的关系，我们检测了299例未经治疗的局部晚期或转移性NSCLC患者的血清该抗原水平。治疗前，有肺转移的患者血清唾液酸化Lewis X-i抗原水平显著高于无肺转移的患者（p = 0.0001）。在初次诊断时无肺转移的201例患者中，121例患者于1987年7月至1995年12月期间死亡。在此期间发生肺转移的21例患者的血清唾液酸化Lewis X-i抗原水平显著高于未发生肺转移的100例患者（p = 0.0171）。我们的结果表明，唾液酸化Lewis X-i抗原可能是肺转移存在或发生的良好指标，并且可能为NSCLC患者的管理提供临床信息。