Gordon E, Lasserre A, Stull P, Bajpai P K, England B
Department of Biology, University of Dayton, OH 45469, USA.
Biomed Sci Instrum. 1997;33:131-6.
Testosterone has been shown to stimulate bone healing. However, large doses of testosterone are associated with liver damage and prostate enlargement. Continuous release of testosterone at the traumatized bone site could enhance healing without inducing systemic side effects. In this investigation a self-setting zinc sulfate calcium phosphate (ZSCAP) ceramic with and without testosterone was used to fill experimentally induced bone defects in rats. Each treatment group consisted of six albino, Holtzman rats. Groups I and II consisted of non-operated and sham-operated animals. Rats in Group III, IV, V, and VI were implanted with ZSCAP particulate ceramic powders (63-75 microns) containing 0.0, 0.5, 1.0, or 1.5 mg testosterone in a 2.3 mm defect in the femur of each rat. Radiographic and morphologic examination of the implant site at four, eight, and twelve weeks post surgery showed integration of the implant in the femur of each rat. Serum testosterone of all rats was assayed at four, eight, and twelve weeks post surgery. Differences in the serum testosterone levels of rats in the six groups were not significant. Results of this study suggest that a ZSCAP-testosterone composite can be used to repair traumatized bone without increasing the levels of testosterone in the systemic circulation.
已证实睾酮能促进骨愈合。然而，大剂量睾酮会导致肝损伤和前列腺增生。在创伤骨部位持续释放睾酮可促进愈合且不会引发全身副作用。在本研究中，使用含与不含睾酮的自固化硫酸锌磷酸钙（ZSCAP）陶瓷填充大鼠实验性诱导的骨缺损。每个治疗组由六只白化霍尔茨曼大鼠组成。第一组和第二组为未手术和假手术动物。第三组、第四组、第五组和第六组大鼠在每只大鼠股骨的2.3毫米缺损处植入含0.0、0.5、1.0或1.5毫克睾酮的ZSCAP颗粒陶瓷粉末。术后四周、八周和十二周对植入部位进行影像学和形态学检查，结果显示植入物与每只大鼠的股骨融合。在术后四周、八周和十二周对所有大鼠的血清睾酮进行检测。六组大鼠血清睾酮水平的差异不显著。本研究结果表明，ZSCAP-睾酮复合材料可用于修复创伤骨，而不会提高体循环中的睾酮水平。
