Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, Nakamura S, Ogawa M, Mitsudomi T, Sugiura T, Takahashi T
Department of Internal Medicine, Aichi Cancer Center Hospital, Nagoya, Japan.
Cancer Res. 1998 Sep 1;58(17):3761-4.
Cyclooxygenase (COX)-2 expression was immunohistochemically examined in 59 human lung cancers as well as in normal and premalignant lung specimens. In contrast to scattered weak reactivity seen in normal peripheral airway epithelial cells, markedly up-regulated COX-2 expression was detected in about one-third of atypical adenomatous hyperplasias and carcinoma in situ specimens, and a significant increase in COX-2 expression was observed in 70% of invasive adenocarcinoma cases. Interestingly, the proportion of adenocarcinoma cells with marked COX-2 expression was much greater in lymph node metastases than in the corresponding primary tumors. In contrast, small cell carcinomas showed virtually negligible expression, and squamous cell carcinomas showed infrequent and low expression. These findings suggest that an increase in COX-2 expression may be associated with the development of adenocarcinomas and possibly with acquisition of an invasive and metastatic phenotype.
采用免疫组织化学方法检测了59例人肺癌以及正常和癌前肺标本中环氧合酶（COX）-2的表达情况。与正常外周气道上皮细胞中散在的弱阳性反应不同，在约三分之一的非典型腺瘤样增生和原位癌标本中检测到COX-2表达明显上调，并且在70%的浸润性腺癌病例中观察到COX-2表达显著增加。有趣的是，与相应的原发性肿瘤相比，淋巴结转移灶中COX-2表达明显的腺癌细胞比例要高得多。相比之下，小细胞癌的表达几乎可以忽略不计，鳞状细胞癌的表达则少见且低。这些发现表明，COX-2表达增加可能与腺癌的发生发展以及侵袭和转移表型的获得有关。
