Kastrup A, Thomas C, Hartmann C, Schabet M
Department of Neurology, University of Tübingen, Germany.
Cephalalgia. 1998 Jul-Aug;18(6):353-7. doi: 10.1046/j.1468-2982.1998.1806353.x.
The prophylactic effect of metoprolol in the treatment of migraine is well known, but its mode of action is still unclear. In the past, increased CO2 reactivity has been reported as one pathognomic finding in interictal migraineurs. Using transcranial Doppler we assessed CO2 reactivity in 20 migraineurs before and 3 h after the first intake of 50 mg metoprolol, and subsequently twice after 1 and 8 weeks of continuous therapy with 150 mg metoprolol/d. Before initiation of therapy, migraineurs as a group had increased CO2 reactivity (p=0.07) compared to 20 age- and sex-matched volunteers. While treatment with metoprolol has been reported to affect amplitudes of increased contingent negative variation or visual evoked potentials in interictal migraineurs, it had no influence on enhanced CO2 reactivity in the present study. Moreover, the pretreatment value of CO2 reactivity did not correlate with the clinical efficacy of metoprolol after a 2-month treatment period.
美托洛尔治疗偏头痛的预防作用已广为人知，但其作用方式仍不清楚。过去，二氧化碳反应性增加被报道为发作间期偏头痛患者的一项特征性发现。我们使用经颅多普勒评估了20名偏头痛患者在首次服用50毫克美托洛尔之前和之后3小时的二氧化碳反应性，随后在连续服用150毫克美托洛尔/天1周和8周后又进行了两次评估。在开始治疗前，与20名年龄和性别匹配的志愿者相比，偏头痛患者作为一个群体的二氧化碳反应性有所增加（p = 0.07）。虽然据报道美托洛尔治疗会影响发作间期偏头痛患者的关联性负变或视觉诱发电位增加的幅度，但在本研究中它对增强的二氧化碳反应性没有影响。此外，在2个月的治疗期后，二氧化碳反应性的预处理值与美托洛尔的临床疗效无关。
