Fiermonte G, Annulli A, Pierelli F
Istituto di Clinica delle Malattie Nervose e Mentali Università La Sapienza, Rome, Italy.
Cephalalgia. 1999 Jun;19(5):492-6. doi: 10.1046/j.1468-2982.1999.019005492.x.
Transcranial Doppler (TCD) recording was used to evaluate the mean flow velocity (MFV) and cerebrovascular reactivity to CO2 in 21 migraineurs during the interictal phase. Nine were affected by migraine with aura (MwA) and 12 by migraine without aura (MwoA). During each session the middle cerebral artery (MCA) flow velocity was examined in basal conditions, in hypocapnia after a 3-min period of hyperventilation, in basal conditions a second time, and in hypercapnia after breath-holding. The same procedure was followed in a group of 21 age- and sex-matched volunteers. Recordings were performed before (T1), during (T2), and after (T3) prophylactic treatment with flunarizine (10 mg/day for 2 months) to assess the possible effect of this drug on cerebral hemodynamics. In basal condition, increased MFV values were found in both MwA and MwoA patients. In MwA patients the reactivity index (RI) to hypocapnia was significantly increased in T1 (p < 0.05). This abnormal cerebrovascular reactivity disappeared during flunarizine treatment (T2) and in the post-therapy period (T3).
采用经颅多普勒（TCD）记录法，在发作间期对21名偏头痛患者的平均血流速度（MFV）和脑血管对二氧化碳的反应性进行评估。其中9名患有伴先兆偏头痛（MwA），12名患有无先兆偏头痛（MwoA）。在每次检查过程中，均在基础状态下、过度通气3分钟后的低碳酸血症状态下、再次基础状态下以及屏气后的高碳酸血症状态下检测大脑中动脉（MCA）的血流速度。对一组21名年龄和性别匹配的志愿者采用相同程序。在使用氟桂利嗪（10毫克/天，持续2个月）进行预防性治疗之前（T1）、治疗期间（T2）和治疗之后（T3）进行记录，以评估该药物对脑血流动力学的可能影响。在基础状态下，MwA和MwoA患者的MFV值均升高。在MwA患者中，T1时对低碳酸血症的反应指数（RI）显著升高（p < 0.05）。这种异常的脑血管反应性在氟桂利嗪治疗期间（T2）和治疗后阶段（T3）消失。
