日本东北地区万古霉素及其他抗菌药物对耐甲氧西林金黄色葡萄球菌和粪肠球菌的体外活性比较

Comparative in vitro activity of vancomycin and other antimicrobial agents against methicillin-resistant staphylococcus aureus and enterococcus faecium in the Tohoku district of Japan.

作者信息

Lutfor A B, Kikuchi T, Tokue Y, Takahashi H, Shoji S, Fujimura S, Nukiwa T, Watanabe A

机构信息

Departmentof Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

出版信息

Chemotherapy. 1998 Sep-Oct;44(5):318-23. doi: 10.1159/000007129.

DOI:10.1159/000007129

PMID:9732146

Abstract

Susceptibility patterns of methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium obtained from various hospitals of the Tohoku district were documented. MICs of 6 antimicrobial agents against a total of 480 strains (380 strains were MRSA and 100 were E. faecium) were estimated. All MRSAs were susceptible to vancomycin, teicoplanin and quinupristin/dalfopristin, but all of them were resistant to ampicillin and benzylpenicillin. None of the E. faecium strains were found to be resistant to vancomycin, teicoplanin and quinupristin/dalfopristin. Excluding these, almost all strains of E. faecium were resistant to the remaining drugs. These data suggest that despite the emergence of vancomycin resistance to E. faecium in Europe and in the United States, vancomycin, teicoplanin and quinupristin/dalfopristin will nevertheless provide effective bactericidal activity in the Tohoku area of Japan.

摘要

记录了从日本东北地区各医院分离出的耐甲氧西林金黄色葡萄球菌（MRSA）和粪肠球菌的药敏模式。评估了6种抗菌药物对总共480株菌株（380株为MRSA，100株为粪肠球菌）的最低抑菌浓度（MIC）。所有MRSA对万古霉素、替考拉宁和奎奴普丁/达福普汀敏感，但对氨苄西林和苄青霉素均耐药。未发现粪肠球菌菌株对万古霉素、替考拉宁和奎奴普丁/达福普汀耐药。除此之外，几乎所有粪肠球菌菌株对其余药物均耐药。这些数据表明，尽管在欧洲和美国已出现粪肠球菌对万古霉素耐药的情况，但在日本东北地区，万古霉素、替考拉宁和奎奴普丁/达福普汀仍将具有有效的杀菌活性。